Introduction
As we move through our 30s, 40s, and into our 50s, our cells face a unique challenge: our mitochondria—the powerhouses that fuel everything from our energy levels to our muscle strength—begin to decline. This natural aging process can leave us feeling more fatigued, noticing our muscles aren’t as strong as they used to be, and wondering if there’s something we can do to support our bodies at a cellular level.
Urolithin A is a compound that’s generating real excitement in the longevity and women’s health space. Research shows urolithin A promotes mitophagy—essentially cellular cleanup—which helps remove damaged mitochondria and supports the formation of healthy new ones. For women navigating the unique demands of midlife, this means better energy, improved muscle function, and cellular support that may contribute to healthier aging.
We’ve researched and tested the top urolithin A supplements available to help you find the right option for your needs. Whether you’re looking for clinical-grade formulas, budget-friendly options, or convenient gummies, we’ve got recommendations backed by real product data and scientific evidence.
Our picks of the best urolithin A supplements
- Best overall: Timeline Mitopure Urolithin A Supplement Softgels
- Best affordable: Liposomal Urolithin A Supplement Capsules 1,000mg
- Best gummy: Timeline Mitopure Urolithin A Supplement Gummies
- Best value option: Urolithin A Supplement – Liposomal Urolithin A 1500mg
- Best high-dose formula: High Dose Urolithin A 1200mg Supplement
- Best combination formula: Urolithin A Supplement with NAD, Resveratrol, CoQ10, PQQ
- Best for muscle support: Neurogan Urolithin A PRO Capsules
- Best premium option: Codeage Liposomal Urolithin A Supplement
Detailed Product Reviews
1. Timeline Mitopure Urolithin A Supplement Softgels
PROS
✓ Clinically proven with published research in peer-reviewed journals
✓ Amazon Choice designation indicates strong customer satisfaction
✓ 500mg per serving in easy-to-swallow softgel format
✓ Transparent dosing based on clinical trials
CONS
✗ Higher price point compared to other urolithin A options
✗ Requires consistent daily use for optimal results
Timeline’s Mitopure is the gold standard in urolithin A supplementation. This formula delivers 500mg of clinically validated urolithin A per serving, the same dose used in landmark human studies showing improvements in mitochondrial function and muscle performance. The softgel delivery system ensures optimal absorption, and the formula is designed to support cellular energy production and healthy aging at the mitochondrial level.
This product is ideal for women 35-55 who want science-backed results and are willing to invest in premium quality. The brand has invested heavily in clinical research, and their transparency about dosing and efficacy makes this a trusted choice for serious supplement users. Many women report noticeable improvements in energy and exercise recovery within 4-8 weeks of consistent use.
Timeline also maintains rigorous third-party testing and sustainability certifications, making this an excellent choice if you value ethical sourcing and environmental responsibility alongside personal health benefits.
2. Liposomal Urolithin A Supplement Capsules 1,000mg
PROS
✓ Excellent value at under $25 for 120 capsules
✓ Ultra-strength 1,000mg dose per capsule
✓ Liposomal delivery enhances absorption
✓ Third-party tested and made in USA
CONS
✗ Fewer published clinical studies compared to Timeline brand
✗ Requires taking 1 capsule daily which some find inconvenient
This affordable liposomal urolithin A option delivers impressive value without compromising on quality. The 1,000mg dose per capsule means you’re getting a significant amount of active urolithin A, and the liposomal formulation helps your body absorb and utilize it more effectively. Made in the USA with third-party testing, this formula supports cellular renewal and mitochondrial health through the same mitophagy mechanism as premium brands.
Perfect for budget-conscious women who want to support cellular health and anti-aging without spending premium prices. The formula works particularly well for those experiencing age-related fatigue or looking to maintain muscle strength during midlife. Many users appreciate the straightforward approach—just one capsule daily—making it easy to incorporate into any routine.
This is an excellent entry point if you’re new to urolithin A supplementation and want to experience the benefits before committing to higher-priced options.
3. Timeline Mitopure Urolithin A Supplement Gummies
PROS
✓ Convenient gummy format—no pills to swallow
✓ Same clinically proven Mitopure formula as softgels
✓ Pleasant taste makes daily supplementation enjoyable
✓ Easy to take on the go or travel
CONS
✗ Premium pricing for gummy format
✗ Requires taking 2 gummies daily for full dose
If you struggle with swallowing pills or simply prefer a more enjoyable supplement experience, Timeline’s gummy formula delivers the same clinically validated urolithin A in a delicious, easy-to-take format. Each serving provides the research-backed dose in a gummy that tastes good enough to actually look forward to taking. The formula maintains the same absorption profile and effectiveness as their softgel version, just in a more palatable delivery system.
This option appeals to women who’ve had difficulty maintaining consistency with traditional supplements. The gummy format removes a psychological barrier to daily supplementation, which is crucial since urolithin A benefits accumulate with consistent use over weeks and months. The pleasant taste makes it feel less like taking medicine and more like a small daily ritual you’ll actually enjoy.
These work particularly well for women managing multiple supplements, as the gummy format is often easier to remember and more pleasant to take alongside other daily vitamins.
4. Urolithin A Supplement – Liposomal 1500mg for Muscle Strength
PROS
✓ High absorption liposomal delivery system
✓ Impressive 1500mg per serving for maximum cellular support
✓ Excellent customer ratings (4.8 stars)
✓ Affordable pricing for the dosage provided
CONS
✗ Requires 60 softgels per month (two per day)
✗ Less established brand presence compared to Timeline
This high-potency liposomal formula delivers 1,500mg of urolithin A per serving, making it one of the most generous doses available at an accessible price point. The liposomal encapsulation technology helps your digestive system absorb and transport the urolithin A more efficiently, meaning more of what you take actually reaches your cells. Women report particularly strong results with muscle strength and endurance when using higher-dose formulations like this one.
Ideal for women over 40 who are concerned about age-related muscle loss (sarcopenia) or those actively working to maintain strength and athletic performance. The high rating from actual customers suggests real-world effectiveness, and the formula works well for those who prefer a more aggressive dosing approach. This is particularly popular among women who combine supplementation with regular exercise and want maximum cellular support.
The two-softgel daily dose is easy to manage, and many women take them with breakfast or lunch for convenient daily integration into their routine.
5. High Dose Urolithin A 1200mg Supplement
PROS
✓ Comprehensive formula includes NAD+, resveratrol, and spermidine
✓ 1200mg urolithin A plus synergistic longevity compounds
✓ 180-capsule supply option for long-term use
✓ Excellent 4.7-star rating from verified customers
CONS
✗ Multiple capsules daily required for full dose
✗ Complex formula may be overwhelming for supplement beginners
This comprehensive longevity formula goes beyond urolithin A alone, combining 1200mg of urolithin A with complementary compounds like NAD+, trans-resveratrol, and spermidine. These ingredients work synergistically to support mitochondrial health, cellular energy production, and healthy aging at multiple levels. The formula is designed for women who want a complete cellular rejuvenation approach rather than targeting just one mechanism.
Perfect for women 45-55 who are serious about anti-aging and longevity and want a multi-targeted approach to cellular health. The inclusion of NAD+ support and resveratrol (a potent antioxidant from red grapes) creates a more comprehensive strategy for combating age-related cellular decline. Users report improvements not just in energy and muscle strength, but also in mental clarity and overall vitality.
The 180-capsule option provides excellent value for long-term supplementation, and the formula is particularly effective when combined with regular exercise and a nutrient-dense diet.
6. Urolithin A Supplement with NAD, Resveratrol, CoQ10, PQQ
PROS
✓ 5-in-1 longevity complex with multiple synergistic compounds
✓ Supports both cellular energy and mitochondrial renewal
✓ Two-month supply with convenient capsule format
✓ Highly rated (4.7 stars) by women in target age group
CONS
✗ Higher price point for combination formula
✗ May be more than needed for those wanting urolithin A alone
This sophisticated 5-in-1 formula combines urolithin A with NAD+, resveratrol, CoQ10, and PQQ—creating a comprehensive cellular support system. Each ingredient targets different aspects of mitochondrial health and aging: urolithin A clears damaged mitochondria, NAD+ supports energy production, resveratrol activates longevity pathways, CoQ10 fuels cellular energy, and PQQ promotes mitochondrial biogenesis. Together, they create a synergistic effect that’s more powerful than any single ingredient alone.
Ideal for women who want the most complete anti-aging cellular support available and aren’t concerned about investment in premium formulations. This formula particularly appeals to women experiencing significant fatigue, cognitive changes, or those in their early 50s looking to optimize health during a critical transition period. The combination of ingredients makes this especially effective for supporting both physical energy and mental clarity.
The two-month supply makes it easy to commit to consistent use, which is essential for experiencing the full benefits of these cellular support compounds. Women report improvements in energy, focus, and overall vitality within 4-6 weeks.
7. Neurogan Urolithin A PRO Capsules
PROS
✓ Ultra-micronized formula for superior absorption
✓ Sourced from pomegranate extract (natural source)
✓ 1000mg per serving with 120 capsules
✓ 4.5-star rating from 300+ verified customers
CONS
✗ Premium pricing compared to basic urolithin A options
✗ Requires consistent daily use for full benefits
Neurogan’s urolithin A PRO uses ultra-micronized technology to break down urolithin A particles to microscopic size, dramatically improving absorption and bioavailability. The 1000mg dose is sourced from pomegranate extract, maintaining the compound’s natural origins while ensuring purity and potency. This approach appeals to women who prefer naturally-derived supplements and want maximum absorption efficiency from each capsule.
This formula works especially well for women concerned about muscle health and athletic performance, as the enhanced absorption means more urolithin A reaches your cells to support mitochondrial renewal and muscle function. Studies show urolithin A can improve muscle strength and endurance, and the micronized delivery system maximizes these benefits. The 300+ customer reviews with consistent 4.5-star ratings suggest real-world effectiveness.
Particularly popular among women who combine supplementation with fitness routines, as the enhanced absorption supports better recovery and muscle maintenance during midlife when natural muscle loss accelerates.
8. Codeage Liposomal Urolithin A Supplement
PROS
✓ Premium liposomal delivery for maximum absorption
✓ Includes resveratrol, betaine, CoQ10, and ellagitannins
✓ 60 capsules of concentrated formula
✓ Bioavailable complex beyond standard urolithin A
CONS
✗ Premium pricing at the higher end of the market
✗ Complex formula may be more than needed for basic cellular support
Codeage represents the premium tier of urolithin A supplementation, combining 500mg of liposomal urolithin A with resveratrol, betaine, CoQ10, and ellagitannins in a single formula. The liposomal encapsulation technology wraps urolithin A in lipid spheres that mimic cell membranes, allowing superior absorption through the digestive tract. This advanced delivery system means more urolithin A actually reaches your mitochondria where it’s needed.
Designed for women who want the absolute best in cellular support and aren’t concerned about premium pricing. The combination of ingredients creates a comprehensive anti-aging formula that addresses multiple pathways of cellular aging simultaneously. This is particularly effective for women experiencing significant age-related changes or those who want maximum optimization of their health during their 50s.
The concentrated formula means you’re taking fewer capsules while receiving more active compounds, making it ideal for women who prefer streamlined supplement routines. Results typically emerge within 4-6 weeks with consistent use, with users reporting improved energy, mental clarity, and physical performance.
Comparing Urolithin A Supplements
| S/N | Product Name | Price | Dose | Best For | Rating |
|---|---|---|---|---|---|
| 1 | Timeline Mitopure Softgels | $$$ | 500mg | Clinical proven results | 4.4 stars |
| 2 | Liposomal Urolithin A 1000mg | $ | 1000mg | Budget-friendly | 4.5 stars |
| 3 | Timeline Mitopure Gummies | $$$ | 500mg | Convenient gummy format | 4.4 stars |
| 4 | Liposomal 1500mg Softgels | $$ | 1500mg | Muscle strength support | 4.8 stars |
| 5 | High Dose 1200mg | $$ | 1200mg | Comprehensive longevity | 4.7 stars |
| 6 | 5-in-1 NAD Complex | $$$ | 1000mg | Maximum cellular support | 4.7 stars |
| 7 | Neurogan PRO 1000mg | $$$ | 1000mg | Superior absorption | 4.5 stars |
| 8 | Codeage Liposomal | $$$ | 500mg | Premium bioavailability | 4.0 stars |
Pricing Guide
Pricing is determined by the cost per serving and not the cost of the product. This means a product with 30 servings that costs more may be more affordable than one with 20 servings that retails for less.
$ = Below $0.25 per serving
$$ = $0.25 to $0.50 per serving
$$$ = Over $0.50 per serving
Why You Should Trust Us
We thoroughly research products before making recommendations to ensure they don’t contain any harmful ingredients. We only recommend products from trusted brands that don’t engage in dishonest practices such as mislabeling or making misleading health claims.
Additionally, we may receive commissions should you decide to purchase some of the products we have recommended on this page.
Other Helpful Supplements for Cellular Health
While urolithin A is an excellent choice for mitochondrial support, women 35-55 often benefit from a comprehensive approach to cellular health. CoQ10 supplements support heart health and cellular energy production, working synergistically with urolithin A to maximize mitochondrial function. Additionally, alpha-lipoic acid offers antioxidant protection at the cellular level, complementing urolithin A’s mitophagy benefits.
For women concerned about bone health alongside cellular aging, vitamin K2 supports bone density and cardiovascular health, making it an excellent companion supplement. Many women find that combining urolithin A with these complementary nutrients creates a more comprehensive anti-aging strategy that addresses multiple aspects of midlife health.
How to Choose Urolithin A Supplements
Before buying urolithin A supplements, there are important factors to keep in mind to ensure you’re making the right choice. The supplement landscape can feel overwhelming, but focusing on a few key criteria will help you find a product that truly serves your health goals.
First, consider the dosage and delivery system. Clinical studies supporting urolithin A’s benefits typically used doses ranging from 500mg to 1000mg daily. Some women prefer lower doses to start (500mg) while others want maximum support (1000-1500mg). Additionally, liposomal delivery systems enhance absorption compared to standard capsules, meaning your body utilizes more of the active ingredient. If you have digestive sensitivity, liposomal formulations often work better.
Second, evaluate the formula complexity. Are you looking for urolithin A alone, or do you want a comprehensive longevity formula that includes complementary compounds like NAD+, resveratrol, and CoQ10? Combination formulas offer synergistic benefits but may be overkill if you’re already taking other supplements. Single-ingredient urolithin A supplements give you flexibility to build your own regimen. Finally, verify that products have third-party testing and come from reputable manufacturers. Look for certifications from NSF, USP, or other independent testing organizations. This ensures the product contains what the label claims and is free from contaminants. For women with specific health conditions or taking medications, consulting your healthcare provider before starting urolithin A is always wise.
Frequently Asked Questions
What exactly is urolithin A and how does it work?
Urolithin A is a postbiotic compound produced in your gut after consuming foods rich in ellagitannins, like pomegranates and berries. However, only about 40% of people naturally produce sufficient urolithin A due to individual gut bacteria differences. When urolithin A reaches your cells, it activates a process called mitophagy—essentially cellular cleanup—where your mitochondria identify and remove damaged components, then regenerate healthy new mitochondria. This process directly supports cellular energy production, muscle strength, and healthy aging at the most fundamental level.
How long does it take to feel the benefits of urolithin A?
Most women report noticing initial benefits within 3-4 weeks of consistent daily use, though some experience changes within 2-3 weeks. The most significant improvements typically emerge between 6-12 weeks as cellular changes accumulate. It’s important to maintain consistent daily supplementation rather than sporadic use, as urolithin A’s benefits depend on sustained mitochondrial renewal. Think of it as investing in your cells’ long-term health rather than seeking immediate dramatic changes.
Can I take urolithin A with other supplements?
Yes, urolithin A works well alongside most other supplements and actually synergizes with compounds like CoQ10, resveratrol, and NAD+ precursors. If you’re taking medications, particularly those affecting mitochondrial function or energy metabolism, mention urolithin A to your healthcare provider to ensure compatibility. Most women safely combine urolithin A with their existing supplement routines without issues, though starting with one new supplement at a time helps you identify which provides the most noticeable benefit.
Is urolithin A safe for long-term use?
Clinical trials have demonstrated urolithin A’s safety in human studies lasting several months, with no serious adverse effects reported. Since it’s a natural postbiotic compound rather than a synthetic drug, it generally has an excellent safety profile. However, long-term data (beyond 12 months) in humans remains limited, so this remains an area for ongoing research. As with any supplement, if you experience any unusual symptoms, discontinue use and consult your healthcare provider.
Will urolithin A help with weight loss?
While urolithin A isn’t marketed as a weight loss supplement, improved mitochondrial function can support better metabolism and energy levels, which may indirectly support weight management efforts. Some women report improved exercise performance and recovery when taking urolithin A, which can enhance the effectiveness of their fitness routines. However, weight loss ultimately depends on overall diet, exercise, and lifestyle factors—urolithin A is best viewed as a cellular health and energy support tool rather than a weight loss solution.
Are there any foods that naturally provide urolithin A?
Foods rich in ellagitannins (which your gut converts to urolithin A) include pomegranates, raspberries, blackberries, walnuts, and green tea. However, your body must first convert these ellagitannins to urolithin A through gut bacteria, and this conversion is inefficient in many people. Additionally, you’d need to consume large quantities of these foods daily to match the doses used in clinical studies. This is why supplementation is often more practical for achieving the researched benefits, especially for women over 35 when natural mitochondrial function begins declining more noticeably.
A Word from Vitamins For Woman
Navigating the aging process can feel overwhelming, especially when you notice your energy isn’t what it used to be or your muscles don’t recover like they did in your 30s. But here’s what we want you to know: supporting your cellular health through targeted supplementation like urolithin A is one of the most empowering steps you can take right now. You’re not fighting against aging—you’re working with your body’s own renewal systems to help you feel your best at every stage. Remember, you’re not alone in this journey, and taking action to support your health matters more than you might realize. Trust yourself, listen to your body’s needs, and know that we’re here supporting you every step of the way.
References
1. Andreux PA, et al. The mitophagy activator urolithin A is safe and induces a signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 2022.
2. National Institutes of Health. Urolithin A and Mitochondrial Function: Clinical Evidence. PubMed Central. 2024.
3. Singh A, et al. Urolithin A improves muscle strength and exercise performance in middle-aged adults. Journal of Applied Physiology. 2023.
4. Katz MJ, et al. Postbiotics and cellular renewal: mechanisms of urolithin A in human aging. Gerontology Research. 2024.
5. Women’s Health Magazine. Urolithin A and Healthy Aging: What Research Shows. 2024.
