Ever feel like your body is working against you with irregular cycles, stubborn weight, or mood swings that just won’t quit? If you’re a woman over 35 dealing with PCOS, you’re not alone—these symptoms can feel especially frustrating as hormones naturally shift during perimenopause. Myo-inositol supplements offer promising support by improving insulin sensitivity, balancing hormones, and promoting ovarian health, which can lead to more regular cycles and better overall well-being.
For women in their 30s, 40s, and 50s, finding the right myo-inositol is key—look for the clinically studied 40:1 ratio of myo-to-d-chiro inositol, third-party testing, and clean formulas without fillers. We’ve researched dozens of options, prioritizing high ratings, variety in forms (capsules, powders, gummies), and features like added folate or vitamin D for enhanced PCOS symptom relief. Here are our top picks to help you find what fits your routine.
Our picks of the best Myo-Inositol Supplements for PCOS
- Best overall: Myo-Inositol & D-Chiro Inositol Supplement For Women (120 Capsules, 2050mg Per Serving Ideal 40:1 Ratio Myo Inositol)
- Best affordable: Inositol Capsules (Myo Inositol) 1000mg Health Support for Women (60 Count) by Double Wood
- Best gummy: Myo-Inositol & D-Chiro Inositol,Inositol Gummies with Vitamin D3, Magnesium Glycinate, Omega-3, Folate & Zinc
- Best vegan: Zazzee Myo-Inositol Capsules, 2000 mg per Serving, 120 Vegan Capsules
- Best for insulin sensitivity: Myo-Inositol & D-Chiro Inositol Capsules with MTHF, Folate, Vitamin D
- Best organic: Micro Ingredients Myo-Inositol & D-Chiro Inositol Powder, 1lb (221 Servings)
- Best for hormone balance: Intimate Rose Myo-Inositol & D-Chiro Inositol Supplement for Women
- Best powder: Myo-Inositol & D-Chiro Inositol Supplement Powder for Women
1. Myo-Inositol & D-Chiro Inositol Supplement For Women (120 Capsules, 2050mg Per Serving Ideal 40:1 Ratio Myo Inositol)
PROS
✓ Clinically studied 40:1 ratio
✓ Third-party tested
✓ Vegan and USA made
✓ High potency 2050mg per serving
CONS
✗ Capsules may be large for some
✗ Requires 2 capsules daily
✗ No added folate
This supplement delivers 2050mg per serving in the ideal 40:1 myo-to-d-chiro inositol ratio, which supports insulin signaling in cells to improve sensitivity—a core issue in PCOS. It helps promote hormone balance by reducing androgen levels and supporting ovarian function, potentially leading to more regular cycles and better metabolic health.
Women over 35 managing PCOS alongside perimenopausal changes will appreciate the clean, third-party tested formula that’s vegan-safe and free from fillers. The high potency stands out for those seeking targeted ovarian health and conception support without unnecessary additives.
Take 2 capsules daily with meals for best absorption; pair with a balanced diet for optimal results.
2. Inositol Capsules (Myo Inositol) 1000mg Health Support for Women (60 Count) by Double Wood
PROS
✓ Budget-friendly high dose
✓ No fillers, vegan safe
✓ Gluten-free
✓ Simple myo-inositol focus
CONS
✗ No d-chiro inositol
✗ Shorter supply per bottle
✗ Basic formula
This product provides 1000mg of pure myo-inositol per serving, acting as a second messenger in insulin pathways to enhance sensitivity and support metabolic function in women with PCOS. It aids in hormone regulation and ovarian health by mimicking insulin’s effects more efficiently.
Ideal for women 35+ starting their PCOS journey or preferring a straightforward, no-frills option. It’s non-GMO, gluten-free, and vegan, making it accessible for sensitive systems.
3. Myo-Inositol & D-Chiro Inositol,Inositol Gummies with Vitamin D3, Magnesium Glycinate, Omega-3, Folate & Zinc
PROS
✓ Tasty gummy format
✓ Comprehensive added nutrients
✓ 40:1 ratio
✓ Supports cycle regulation
CONS
✗ Lower potency per gummy
✗ Sugar content
✗ Multiple daily servings
These gummies combine myo and d-chiro inositol in a 40:1 ratio with supportive nutrients like vitamin D3, magnesium, and folate to enhance insulin sensitivity and hormone balance. The blend targets PCOS symptoms by improving ovarian response and reducing insulin resistance.
Suited for women 35-55 who dislike capsules and want an easy, flavorful way to support feminine wellness. The added zinc and omega-3 promote overall hormone and mood stability.
Enjoy 2-4 gummies daily; great for on-the-go use.
4. Zazzee Myo-Inositol Capsules, 2000 mg per Serving, 120 Vegan Capsules
PROS
✓ 100% vegetarian
✓ High 2000mg dose
✓ Ideal for 40:1 ratio needs
✓ Non-GMO
CONS
✗ Capsules only
✗ No combo inositol
Offering 2000mg myo-inositol per serving, this supplement supports healthy ovarian function and hormone balance by aiding insulin pathways crucial for PCOS management. It promotes cellular health and metabolic improvements.
Perfect for vegan women over 35 seeking a potent, all-natural option without GMOs. The generous supply makes it convenient for long-term use in supporting cycle regularity.
5. Myo-Inositol & D-Chiro Inositol Capsules with MTHF, Folate, Vitamin D
PROS
✓ Includes folate and vitamin D
✓ 40:1 ratio
✓ Supports homocysteine levels
✓ Ovarian focus
CONS
✗ Higher serving size
✗ Potential folate sensitivity
This formula features myo and d-chiro inositol in 40:1 ratio plus MTHF folate and vitamin D to optimize hormone balance and ovarian support while addressing insulin resistance common in PCOS.
Best for women 35+ with fertility goals or folate needs; the active folate form enhances bioavailability for better results in cycle support and metabolic health.
6. Micro Ingredients Myo-Inositol & D-Chiro Inositol Powder, 1lb (221 Servings)
PROS
✓ Bulk supply, great value
✓ Pure, filler-free
✓ Vegan, non-GMO
✓ 40:1 ratio
CONS
✗ Powder requires mixing
✗ Unflavored taste
The powder provides myo and d-chiro inositol in 40:1 ratio for hormonal balance and ovarian health, supporting insulin sensitivity without fillers for clean supplementation.
Ideal for cost-conscious women 35-55 wanting long-term PCOS management; versatile for smoothies or water.
Mix 1 scoop daily; store in cool, dry place.
7. Intimate Rose Myo-Inositol & D-Chiro Inositol Supplement for Women
PROS
✓ Added ashwagandha and vitamin D3
✓ 40:1 ratio
✓ Hormone and stress support
✓ Ovarian focused
CONS
✗ Adaptogen may not suit all
✗ Capsule size
Combining 40:1 inositol with vitamin D3 and ashwagandha, this supports insulin sensitivity, hormone balance, and stress reduction for comprehensive PCOS relief and ovarian health.
Great for women over 35 juggling PCOS with daily stress; ashwagandha adds cortisol support.
8. Myo-Inositol & D-Chiro Inositol Supplement Powder for Women
PROS
✓ Powder alternative to capsules
✓ 40:1 ratio, vitamin B8
✓ 30 servings
✓ Ovarian function support
CONS
✗ Mixing required
✗ Mild taste
✗ Shorter supply
This powder offers myo and d-chiro inositol in 40:1 ratio as vitamin B8 to aid healthy ovarian function and hormone balance, bypassing capsule swallowing.
Suitable for women 35+ preferring powders for better absorption in PCOS symptom management.
Mix with water or juice daily.
Comparing Myo-Inositol Supplements for PCOS
| S/N | Product Name | Price | Dose | Best for | Rating |
|---|---|---|---|---|---|
| 1 | Myo-Inositol & D-Chiro Inositol Supplement For Women (120 Capsules, 2050mg) | $ | 2 capsules | overall | 4.6 stars |
| 2 | Inositol Capsules by Double Wood | $ | 1 capsule | affordable | 4.5 stars |
| 3 | Myo-Inositol & D-Chiro Inositol Gummies | $$ | 4 gummies | gummy | 4.5 stars |
| 4 | Zazzee Myo-Inositol Capsules | $$ | 2 capsules | vegan | 4.5 stars |
| 5 | Myo-Inositol & D-Chiro with Folate | $$$ | 2 capsules | insulin sensitivity | 4.6 stars |
| 6 | Micro Ingredients Powder | $$ | 1 scoop | organic | 4.6 stars |
| 7 | Intimate Rose Supplement | $$ | 2 capsules | hormone balance | 4.6 stars |
| 8 | Myo-Inositol Powder for Women | $$ | 1 scoop | powder | 4.6 stars |
Pricing Guide
Pricing is determined by the cost per serving and not the cost of the product. This means a product with 30 servings that cost more may be more affordable than one with 20 servings that retails for less.
$ = Below $0.25 per serving
$$ = $0.25 to $0.50 per serving
$$$ = Over $0.50 per serving
Why You Should Trust Us
We thoroughly research products before making recommendations to ensure they don’t contain any harmful ingredients. We only recommend products from trusted brands that don’t engage in dishonest practices such as mislabeling or making misleading health claims.
Additionally, we may receive commissions should you decide to purchase some of the products we have recommended on this page.
Other helpful supplements
If you’re managing PCOS, consider pairing myo-inositol with supplements like blood sugar support options such as chromium or berberine for enhanced insulin sensitivity. Magnesium can further aid hormone balance and sleep, especially useful during perimenopause.
For comprehensive wellness, explore hormone-balancing blends or probiotics for gut health, which influences PCOS symptoms. Check our guide on reducing PCOS belly fat for diet tips.
How to choose Myo-Inositol Supplements for PCOS
Before buying myo-inositol supplements for PCOS, there are important factors to keep in mind to ensure you’re making the right choice. Some of which include price considerations per serving, as bulk powders often provide better long-term value despite upfront costs. Ingredient quality matters—prioritize the 40:1 myo-to-d-chiro ratio backed by research for optimal insulin and ovarian support, along with third-party testing for purity.
Brand reputation and independent testing are crucial to avoid contaminants; look for non-GMO, vegan options if needed. Dosage should align with studies (around 2000-4000mg myo-inositol daily), and added nutrients like folate or vitamin D can enhance benefits for hormone balance without overcomplicating the formula. Form (capsule, powder, gummy) should fit your lifestyle for consistent use.
Frequently Asked Questions
Does myo-inositol help with PCOS symptom relief?
Yes, research shows myo-inositol improves insulin sensitivity and reduces androgens in PCOS, leading to better cycles and metabolic health. It’s particularly helpful for symptom relief like irregular periods and hirsutism.
What’s the best myo-inositol supplement for hormone balance?
Supplements with the 40:1 ratio, like our top picks, excel for hormone balance by supporting ovarian health and SHBG levels. Consistency over 3-6 months yields the best results alongside lifestyle changes.
How long does myo-inositol take to work for PCOS?
Many women notice cycle improvements in 3 months, with metabolic benefits sooner. Studies confirm effects on insulin sensitivity within weeks, but full ovarian support may take 6 months.
Is myo-inositol safe for women over 35 with PCOS?
Generally safe with mild side effects; it’s well-tolerated compared to metformin. Consult your doctor, especially if pregnant or on medications, for personalized advice.
Can myo-inositol support conception in PCOS?
Yes, by restoring ovulation through better insulin and hormone function. Paired with folate, it’s popular for fertility support in women trying to conceive.
A Word from Vitamins For Woman
PCOS can feel like an uphill battle, especially in your 30s, 40s, and 50s when life’s demands peak and hormones shift. But with tools like myo-inositol, you can take meaningful steps toward balance, clearer skin, regular cycles, and renewed energy. You’re not alone—many women reclaim their vitality through informed choices. Listen to your body, work with your healthcare provider, and celebrate small wins. You’ve got the strength to thrive.
References
- Unfer V, et al. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Gynecol Endocrinol. 2017.
- Teede H, et al. Inositol is an effective and safe treatment in polycystic ovary syndrome. Gynecol Endocrinol. 2023.
- SOGC. Inositol for the Management of Polycystic Ovary Syndrome. 2025.
- Costello MF, et al. Inositol for Polycystic Ovary Syndrome: A Systematic Review. J Clin Endocrinol Metab. 2024.
- Cleveland Clinic. Inositol: Benefits & Side Effects. Accessed 2025.
