Table of Contents
Introduction
Menopause is a natural stage of life, but it often brings along some tough changes, like hot flashes, mood swings, achy joints, and trouble sleeping.
While hormone replacement therapy (HRT) is a conventional approach, many women between 45 and 60 are seeking natural alternatives to manage menopause symptoms. One promising solution that continues to gain scientific support is omega-3 fatty acids.
Known for their anti-inflammatory properties and cardiovascular benefits, omega-3s also show potential in easing menopause-related symptoms.
This article explores the omega-3 benefits for menopause, including relief from hot flashes, mood regulation, and protective effects on heart and bone health.
Whether new to omega-3s or evaluating supplements, you’ll find fact-based guidance here, grounded in research and clinical insight.
How Omega-3s Help Menopause Symptoms
Omega-3 fatty acids are healthy fats your body needs to work correctly, but can’t make them independently. This implies that you have to get them from food or supplements.
Two crucial types—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—are primarily found in fatty fish like salmon and algae.
New research shows that omega-3s may help relieve common menopause symptoms like hot flashes, mood swings, and changes in heart and bone health.
Hot Flashes & Night Sweats Reduction
Hot flashes are one of the most common and disruptive menopause symptoms, affecting up to 75% of women. While the exact cause is not fully understood, it is believed to involve changes in thermoregulation due to declining levels of estrogen.
A randomized controlled trial found that women taking omega-3 supplements experienced a significant reduction in both the frequency and severity of hot flashes compared to a placebo group.
The anti-inflammatory action of EPA may influence brain regions involved in temperature control, helping to stabilize the body’s internal thermostat.
Another study from the North American Menopause Society supports these findings, highlighting that EPA-rich omega-3s—not just general fish oil—may be particularly effective in reducing vasomotor symptoms like hot flashes and night sweats.
Mood Support
Menopause can increase the risk of depression and anxiety, partly due to hormonal fluctuations. Omega-3s, particularly EPA, play a role in brain health and neurotransmitter regulation.
Several studies have concluded that omega-3 supplementation may improve symptoms of depression, especially in women with hormonal imbalances. EPA has been shown to reduce inflammatory cytokines affecting mood and brain function.
In menopause, where estrogen levels drop and serotonin production may decline, omega-3s offer neuroprotective benefits that support mental well-being.
Heart & Bone Health Protection
After menopause, a woman’s risk of heart disease goes up because her body makes less estrogen, which usually helps protect the heart.
Omega-3s—especially those called EPA and DHA—can help lower this risk by reducing fats in the blood, lowering blood pressure, and keeping blood vessels healthy.
Omega-3s may also help protect bones, which can become weaker after menopause. Most people know calcium and vitamin D are essential for bones, but omega-3s help too by reducing inflammation in the body and slowing down the process that breaks down bone.
One study found that women with more EPA and DHA had stronger bones. Omega-3s also help the body use calcium better and reduce cell activity that breaks down bone tissue.
Best Omega-3 Sources for Menopause
To enjoy the full omega-3 benefits for menopause, focus on high-quality sources that provide adequate EPA and DHA.
Fatty Fish
Fatty fish remains the gold standard for dietary omega-3s. Salmon, mackerel, sardines, anchovies, and herring are all excellent sources, offering substantial amounts of both EPA and DHA.
For menopause support, aim for at least two servings of fatty fish per week. This aligns with guidelines from the American Heart Association and provides approximately 500–1,000 mg/day of combined EPA and DHA.
Canned sardines and salmon are budget-friendly, shelf-stable, and contain most of the omega-3 content.
Algae Oil
If you’re vegan or don’t eat fish, algae oil is your best option for omega-3s.
Plant foods like flaxseeds and chia seeds contain a type of omega-3 called ALA, but your body has to convert ALA into the forms it needs—EPA and DHA—and it doesn’t do that well. Algae oil, on the other hand, gives you DHA directly and often includes some EPA too.
A study found that algae oil can raise your levels of DHA and EPA in the blood, making it a reliable vegan source of omega-3s for menopause support.
Choosing the Right Supplement
With so many options on the market, it’s essential to choose omega-3 supplements that meet your specific health needs during menopause.
EPA vs. DHA Ratios
While both EPA and DHA are beneficial, research suggests EPA may be more effective in alleviating hot flashes and mood symptoms. DHA, on the other hand, is crucial for brain and eye health.
Look for supplements that list the exact amounts of EPA and DHA on the label. For menopausal support, a higher EPA-to-DHA ratio, such as 3:2 or 2:1, may be ideal.
Some high-quality options labeled as the best omega-3 supplements for menopause are third-party tested, contain triglyceride-form omega-3s (for better absorption), and have minimal fillers.
Recommended Dosage
Most studies showing benefits for menopause symptoms used doses between 1,000–2,000 mg/day of combined EPA and DHA. It’s essential to check the actual omega-3 content on the supplement label, not just the total fish oil amount.
Start with 1,000 mg/day and increase as needed, especially if targeting specific symptoms like mood or hot flashes. As always, consult a healthcare provider before starting a new supplement, particularly if you’re on blood-thinning medications.
Frequently Asked Questions
Clinical improvements in mood or hot flashes typically appear within 6 to 12 weeks of consistent supplementation. Effects may vary depending on baseline omega-3 levels and overall health.
Flaxseed provides ALA, a plant-based omega-3 that must be converted to EPA and DHA. Unfortunately, the conversion rate is very low (often less than 5%). While flaxseed is a healthy food rich in fiber and lignans (which may help with estrogen metabolism), it is not equivalent to fish oil in omega-3 content.
Fish oil or algae oil remains superior for meaningful EPA and DHA intake.
Indirectly, yes. Omega-3s may support healthy metabolism by reducing inflammation, improving insulin sensitivity, and regulating appetite hormones like leptin.
Although not a weight-loss supplement per se, omega-3s can be a helpful part of a holistic approach to weight management during menopause.
Final thoughts for you
Navigating menopause doesn’t have to mean enduring discomfort or relying solely on pharmaceutical interventions.
Omega-3 fatty acids—mainly EPA and DHA—offer a well-researched, natural option for alleviating hot flashes, mood swings, and supporting long-term heart and bone health.
Whether incorporating more salmon into your diet, exploring algae-based vegan options, or selecting a targeted supplement, omega-3s are foundational in your menopause wellness strategy.
Always choose third-party tested supplements tailored to your unique needs—and don’t hesitate to speak with a healthcare provider before starting something new.
As a pharmacist, I advocate for science-backed choices that honor your body’s natural transitions. Omega-3s are one such ally—gentle, powerful, and backed by evidence.
Iqbal AZ, Wu SK, Zailani H, et al. Effects of omega-3 polyunsaturated fatty acids intake on vasomotor symptoms, sleep quality and depression in postmenopausal women: a systematic review. Nutrients. 2023;15(19):4231.
Office of dietary supplements – omega-3 fatty acids.
Freeman MP, Hibbeln JR, Silver M, et al. Omega-3 fatty acids for major depressive disorder associated with the menopausal transition: a preliminary open trial. Menopause (New York, NY). 2011;18(3):279.
Cohen LS, Joffe H, Guthrie KA, et al. Efficacy of omega-3 treatment for vasomotor symptoms: a randomized controlled trial: omega-3 treatment for vasomotor symptoms. Menopause (New York, NY). 2014;21(4):347.
Dighriri IM, Alsubaie AM, Hakami FM, et al. Effects of omega-3 polyunsaturated fatty acids on brain functions: a systematic review. Cureus. 2022;14(10):e30091.
Abou-Saleh H, Ouhtit A, Halade GV, Rahman MM. Bone benefits of fish oil supplementation depend on its epa and dha content. Nutrients. 2019;11(11):2701.
Rimm EB, Appel LJ, Chiuve SE, et al. Seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease: a science advisory from the american heart association. Circulation. 2018;138(1).
García-Maldonado E, Alcorta A, Zapatera B, Vaquero MP. Changes in fatty acid levels after consumption of a novel docosahexaenoic supplement from algae: a crossover randomized controlled trial in omnivorous, lacto-ovo vegetarians and vegans. European Journal of Nutrition. 2022;62(4):1691.
Swanson D, Block R, Mousa SA. Omega-3 fatty acids epa and dha: health benefits throughout life. Advances in Nutrition. 2012;3(1):1.
Epa / dha: a review of clinical use and efficacy | nutritional medicine institute.
